Succinate-semialdehyde dehydrogenase (NAD(P)+)

In enzymology, a succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16) is an enzyme that catalyzes the chemical reaction

succinate semialdehyde + NAD(P)+ + H₂O succinate + NAD(P)H + 2 H⁺

The 4 substrates of this enzyme are succinate semialdehyde, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are succinate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is succinate-semialdehyde:NAD(P)+ oxidoreductase. Other names in common use include succinate semialdehyde dehydrogenase (nicotinamide adenine, dinucleotide (phosphate)), and succinate-semialdehyde dehydrogenase [NAD(P)+]. This enzyme participates in 3 metabolic pathways: glutamate metabolism, tyrosine metabolism, and butanoate metabolism.

References

• Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
• JAKOBY WB, SCOTT EM (1959). "Aldehyde oxidation. III. Succinic semialdehyde dehydrogenase". J. Biol. Chem. 234 (4): 937–40. PMID 13654295. 
• Nirenberg MW and Jakoby WB (1960). "Enzymatic utilization of gamma-hydroxybutyric acid". J. Biol. Chem. 235: 954–960. PMID 14427301.